路易体病所致痴呆

定义

路易体病患者在出现运动性帕金森症状之前或之后一年内出现的痴呆。以存在路易体为特征，路易体是脑干、边缘区、前脑和新皮质中含有α突触核蛋白和泛素的神经元间内包涵体。发病隐匿，常伴有注意力和执行功能障碍。这些认知障碍通常伴有视幻觉和快速眼动睡眠行为障碍症状。也可能出现其他感官模式的幻觉、抑郁症状和妄想。症状表现通常在数天内变化很大，因此需要进行纵向评估并与谵妄相鉴别。在认知症状出现后约 1 年内常出现自发性帕金森病的情况。

Dementia preceding or occurring within one year after the onset of motor parkinsonian signs in the setting of Lewy body disease. Characterized by presence of Lewy bodies, which are intraneuronal inclusions containing α-synuclein and ubiquitin in the brain stem, limbic area, forebrain, and neocortex. Onset is insidious with attentional and executive functioning deficits often present. These cognitive deficits are often accompanied by visual hallucinations and symptoms of REM sleep behaviour disorder. Hallucinations in other sensory modalities, depressive symptoms, and delusions may also be present. The symptom presentation usually varies significantly over the course of days necessitating longitudinal assessment and differentiation from delirium. Spontaneous onset of Parkinsonism within approximately 1 year of the onset of cognitive symptoms is common.

索引词 可用于检索该条目的同义词与别名

• 路易体病所致痴呆
• 路易体型痴呆
• 路易体痴呆
• SDLT[路易体型老年痴呆]
• 路易体型老年痴呆

编码备注 Coding note

这些分类不可用作主要编码。当需要标识分类于他处的疾病引起的痴呆时，可将这些编码作为补充或附加编码。 对于多种病因引起的痴呆，对所有适用的病因进行编码。

This category should never be used in primary tabulation. The codes are provided for use as supplementary or additional codes when it is desired to identify the presence of dementia in diseases classified elsewhere. When dementia is due to multiple aetiologies, code all that apply.