炎性包涵体肌炎
Inflammatory inclusion body myositis
- 上级条目
- 4A41.2 包涵体肌病
- 层级
- 5 级
定义
包涵体肌炎（IBM）是50岁以后最常见的特发性炎症性肌病。通常表现为慢性隐匿性近端腿部和/或远端手臂不对称性肌无力，导致反复跌倒和丧失灵活性。IBM的肌酸激酶升高达15倍，针式肌电图大多显示为慢性刺激性肌病。肌肉组织病理学显示内膜炎性渗出物围绕和侵入非坏死肌肉纤维，有时还伴有边缘空泡和蛋白质沉积。尽管有炎症性肌肉病变，但IBM可能有突出的退行性成分，是对免疫抑制疗法的支持。
Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy after age 50. It typically presents with chronic insidious proximal leg and/or distal arm asymmetric muscle weakness leading to recurrent falls and loss of dexterity. Creatine kinase is up to 15 times elevated in IBM and needle electromyography mostly shows a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibres often times accompanied by rimmed vacuoles and protein deposits. Despite inflammatory muscle pathology, it is likely that IBM has a prominent degenerative component as supported by refractoriness to immunosuppressive therapy.
除外词 明确排除、需编到其他条目的情况
索引词 可用于检索该条目的同义词与别名
- 炎性包涵体肌炎
- 炎性IBM[炎性包涵体肌炎]
- 散发性包涵体肌炎
- 遗传性包涵体肌炎
- UPD-GlcNac差向异构酶/激酶缺陷
- 家族性包涵体肌炎
英文词条（6）
- Inflammatory inclusion body myositis
- Inflammatory IBM - [inflammatory inclusion body myositis]
- Sporadic inclusion body myositis
- Hereditary inclusion body myositis
- Familial inclusion body myositis
- UPD-GlcNac epimerase/kinase deficiency
后组配轴 Postcoordination
该条目未定义后组配轴，直接使用上面的编码即可。后组配是在主干编码之后追加侧别、具体解剖部位、严重程度、病因等细节的可选组合方式，不是必填项。