副肿瘤性多发性肌炎

定义

副肿瘤是一种罕见的癌症相关实体。表现为亚急性或急性近端无力，通常包括颈屈肌、吞咽困难，很少累及呼吸肌和心脏。有时会出现肌肉疼痛或肌痛。肌肉病理学显示，肌周结缔组织和周围血管内的局部炎症区域中，细胞介导的淋巴细胞对肌肉纤维具有靶向性毒性。肌肉纤维可能被细胞毒性T细胞破坏。 非霍奇金淋巴瘤、肺癌和膀胱癌是最常见的相关癌症类型。

Paraneoplastic is a rare cancer associated entity. It presents sub-, or acutely with proximal weakness, often including the neck flexors, dysphagia, rarely the respiratory muscles and the heart are involved. Sometimes muscle pain or myalgia occur. Myopathology shows a targeted, cell-mediated lymphocyte toxicity against muscle fibres in focal areas of inflammation within perimysial connective tissue and surrounding blood vessels. Muscle fibres may be destroyed by cytotoxic T cells. Non-Hodgkin’s lymphoma, lung, and bladder carcinoma are the most frequently observed associated cancer types.

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• 副肿瘤性多发性肌炎
• 副肿瘤性多肌炎