原发性侧索硬化

定义

原发性侧索硬化症（PLS）是一种罕见的运动神经元疾病变体，表现为缓慢进行性UMN症状，如痉挛步态、急促的深部肌腱痉挛和足底伸肌反应。发病最常见的是痉挛性截瘫，但患者通常会发展为上肢和延髓受累。PLS的特征是完全没有下运动神经元受累。当LMN症状在病程中发展时，诊断将改为ALS，它们被认为是同一疾病的一个谱系。

Primary lateral sclerosis (PLS) is a rare motor neuron disease variant which presents with slowly progressive UMN signs, such as spastic gait, brisk deep tendon jerks, and extensor plantar responses. Onset is most commonly with spastic paraparesis, but patients typically progress to develop upper limb and bulbar involvement. The characteristic feature of PLS is the complete absence of involvement of lower motor neuron involvement. When LMN signs develop during the course of the disease, the diagnosis will change to ALS, and they are considered a spectrum of the same disorder.

索引词 可用于检索该条目的同义词与别名

• 原发性侧索硬化
• 脊髓侧索硬化
• 侧身完全性瘫痪
• 侧身不完全性瘫痪
• 侧身瘫痪
• PLS[原发性侧索硬化] [possible translation]
• 侧索硬化 [possible translation]
• PLS[原发性侧索硬化]
• 侧索硬化