药源性重症肌无力

定义

有些药物对重症肌无力有明显疗效，包括神经肌肉接头阻滞剂、抗生素、强的松、氯喹、D-青霉胺、干扰素等。在快速发作的药物性重症肌无力中，肌无力症状在几天内出现，停药后迅速消失。抗乙酰胆碱酯酶抗体缺失。这种疾病可能掩盖了预先存在的神经肌肉传递障碍，或可能加重预先存在的重症肌无力，即亚临床重症肌无力在药物治疗后变得明显，或已知的MG变得更严重。某些药物与重症肌无力的加重有关，包括疼痛管理药物、三环类抗抑郁药和一些抗癫痫药物，应谨慎使用。

Some drugs can have clear effects on Myasthenia Gravis, including Neuromuscular junction blockers, antibiotics, prednisone, chloroquine, D-penicillamine, interferons, and others. In rapid-onset drug-induced Myasthenia Gravis, myasthenic signs develop within days which rapidly disappear after drug withdrawal. Anti-Acetylcholinesterase antibodies are absent. This disorder may unmask a pre-existing neuromuscular transmission disorder or may exacerbate pre-existing Myasthenia Gravis, i.e. subclinical Myasthenia Gravis becomes manifest after drug treatment, or known MG becomes more severe. Certain drugs are linked with aggravation of Myasthenia Gravis, including pain management medications, tricyclic antidepressants and some antiepileptic medications, and should be used with caution.

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• 药源性重症肌无力
• 药源性重症肌无力