表皮内鳞状细胞癌
Intraepidermal squamous cell carcinoma
- 上级条目
- 2E64 皮肤原位癌
- 层级
- 4 级
定义
局限于外生殖器皮肤表皮的恶性鳞状瘤，俗称鲍温病。它最常出现在长期暴露在阳光下的头颈部或小腿的无毛皮肤上。典型表现为单个或多个界限清楚的鳞状红斑、结节或斑块，组织学上表现为广泛的角质形成细胞异型性。它可能由先前存在的光化性角化病（光化性表皮内鳞状细胞癌）发展而来。虽然它通常与紫外线辐射有关，但也可能与砷和焦油等其他致癌物质有关。人乳头状瘤病毒可能是免疫抑制患者的另一个危险因素。
It arises most frequently on chronically sun-exposed glabrous skin of the head and neck or lower legs. It typically presents as single or multiple well-demarcated scaly erythematous patches, nodules or plaques which histologically show extensive keratinocytic atypia. It may develop from preexisting actinic keratosis (Actinic intraepidermal squamous cell carcinoma). Although it is most commonly associated with exposure to ultraviolet radiation, other carcinogens such as arsenic and tar may be implicated. Human papilloma virus may represent an additional risk factor in immunosuppressed patients.
子条目 共 4 条
后组配轴 Postcoordination
后组配是在主干编码之后追加的可选扩展轴（如侧别、具体解剖部位、严重程度），用于把「部位 + 侧别 + 病程」等细节一次表达完整。只有标注「必填」的轴在组合编码时必须给出，其余可留空。
- 具体解剖部位specificAnatomy可选
- 组织病理histopathology可选
- 临床表现hasManifestation可选