移植物抗宿主病

定义

移植物抗宿主病（GVHD）是指免疫活性供体的淋巴细胞被导入组织不相容的受体而不能排斥它们。这通常是造血干细胞移植的结果。供者淋巴细胞攻击的主要靶点是受者的皮肤、胃肠道和肝脏。急性移植物抗宿主病通常发生在移植后100天内，死亡率很高。急性期之后可能出现慢性移植物抗宿主病，也可能是新发的。通常表现为苔藓样皮疹，但可以发展成严重纤维化疾病影响皮肤，肺和肝脏。

Graft-versus-host disease (GVHD) occurs when lymphoid cells from an immunocompetent donor are introduced into a histo-incompatible recipient incapable of rejecting them. This usually occurs as a result of haematopoietic stem cell transplantation. The main targets attacked by the donor lymphocytes are the recipient’s skin, gastrointestinal tract and liver. Acute GVHD, normally occurring within the first 100 days following transplantation, has a high mortality. The acute phase may be followed by chronic GVHD, which can also arise de novo. This usually presents as a lichenoid rash but can develop into a severe fibrosing disease affecting skin, lungs and liver.

子条目 共 4 条

• 4B24.0急性移植物抗宿主病
• 4B24.1慢性移植物抗宿主病
• 4B24.Y其他特指的移植物抗宿主病
• 4B24.Z未特指的移植物抗宿主病