胫前黏液性水肿

定义

胫前粘液性水肿是一种弥漫性皮肤粘液沉积症，其中真皮和皮下积聚过量的粘多糖，尤其是透明质酸。最常见于胫骨（胫前区），但也发生在下肢的其他部位。它表现为紫色或褐色、坚实、无凹痕、不对称结节或斑块或结节，这些结节往往聚集在一起，形成广泛具有 "peau d'orange"（橘皮）外观的硬结区域。 它几乎总是与自身免疫性甲状腺炎（Graves病）有关，也可能与杵状指（肢端肥大）和突眼（甲状腺眼病）有关。

Pretibial myxoedema is a form of diffuse cutaneous mucinosis in which there is an accumulation of excess glycosaminoglycans, especially hyaluronic acid, in the dermis and subcutis. It is most commonly seen on the shins (pretibial areas) but does occur elsewhere on the lower extremities. It manifests as violaceous or brownish, firm, non-pitting, asymmetrical nodules or plaques or nodules which tend to coalesce to produce extensive areas of induration with a "peau d'orange" (orange peel) appearance. It is nearly always associated with autoimmune thyroiditis (Graves disease) and may be associated with finger clubbing (acropachy) and exophthalmos (thyroid eye disease).

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• 胫前黏液性水肿