药源性Stevens-Johnson综合征

定义

这是药物严重皮肤不良反应（SCARs）的四种主要形式之一，以皮肤和粘膜炎症、水疱和糜烂为特征。根据定义，至少有一个粘膜受累，皮肤脱落限于体表面积的10%以下。大多数病例发生在药物接触的前8周内。最常涉及的药物是抗菌磺胺类药物、抗惊厥药、别嘌醇、奈韦拉平和奥昔康——非甾体抗炎药。

This is one of the four principal forms of severe cutaneous adverse reaction to drugs (SCARs) and is characterised by inflammation, blistering and erosion of skin and mucous membranes. By definition, there is involvement of at least one mucous membrane and skin detachment is limited to less than 10% of body surface area. Most cases occur within the first 8 weeks of drug exposure. The drugs most commonly involved are antimicrobial sulfonamides, anticonvulsants, allopurinol, nevirapine and oxicam–nonsteroidal anti-inflammatory drugs.

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• 药源性Stevens-Johnson综合征