弥漫性光线性表皮发育不良

定义

弥漫性光化性发育不良是在皮肤反复暴露于紫外线辐射后（通常超过几十年）发生的，是由表皮角质细胞核内累积的DNA损伤造成的。最初表现为轻微弥漫性皮肤变化，包括斑点、红斑、毛细血管扩张和不规则细鳞屑。最常见于秃头男性无保护头皮皮肤上。组织学上，基底表皮有发育不良的早期迹象。随着损伤累积，临床变化更加明显，形成不连续光化性角化病，由此可能发展为表皮内或浸润性鳞状细胞癌。

Diffuse actinic dysplasia develops after repeated exposure of skin to ultraviolet radiation, usually over decades, and results from cumulative DNA damage within the nuclei of epidermal keratinocytes. It is characterised initially by subtle diffuse skin changes including mottling, erythema, telangiectasia and irregular fine scaling. It is seen most commonly on the unprotected scalp skin of bald men. Histologically there are early signs of dysplasia in the basal epidermis. As damage accumulates the clinical changes become more pronounced with the formation of discrete actinic keratoses, from which intraepidermal or invasive squamous cell carcinoma may develop.

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• 弥漫性光线性表皮发育不良
• 弥漫性光化性发育不良
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