唐氏综合征相关性髓系增殖

定义

发生在唐氏综合征患者身上的髓系肿瘤。患有唐氏综合征的儿童和成人患急性白血病的风险都会增加。特别是5岁以下的唐氏综合征儿童急性髓系白血病的发病率特别高，它通常是急性巨核细胞白血病，并与GATA1基因突变有关。这组疾病还包括发生在新生儿中的暂时性骨髓增生异常，与GATA1基因突变有关。

Myeloid neoplasms occurring in individuals with Down syndrome. There is an increased risk of acute leukaemias in both children and adults with Down syndrome. In particular, the incidence of acute myeloid leukaemia in Down syndrome children of less than five years of age is particularly high, it is usually an acute megakaryoblastic leukaemia, and is associated with GATA1 gene mutation. This group of disorders also includes the entity transient abnormal myelopoiesis which occurs in neonates and is associated with GATA1 gene mutation.

子条目 共 4 条

• 2A60.40短暂性骨髓细胞生成异常
• 2A60.41唐氏综合征相关性髓系白血病
• 2A60.4Y其他特指的唐氏综合征相关性髓系增殖
• 2A60.4Z未特指的唐氏综合征相关性髓系增殖