药物性红斑狼疮

定义

药物性红斑狼疮是一种抗核抗体阳性综合征，其症状包括发热、乏力、关节炎、剧烈关节痛/肌痛、浆膜炎和/或皮疹。该综合征出现在某些药物（如普鲁卡因胺、肼嗪、苯妥英钠）和肿瘤坏死因子抑制剂治疗期间。它主要发生在白种人中，好发于女性的情况比SLE少，很少涉及肾脏或大脑，很少与抗dsDNA有关，通常与组蛋白抗体有关，通常在停药几周后消退。

Drug-induced lupus erythematosus is a syndrome in which positive antinuclear antibodies are associated with symptoms, such as fever, malaise, arthritis, intense arthralgia/myalgia, serositis, and/or rash. The syndrome appears during therapy with certain medications (e.g., procainamide, hydralazine, phenytoin) and tumour necrosis factor inhibitors. It occurs predominantly in Caucasians, has less female predilection than SLE, rarely involves kidneys or brain, is rarely associated with anti-dsDNA, is commonly associated with antibodies to histones, and usually resolves over several weeks after discontinuation of the offending medication.

索引词 可用于检索该条目的同义词与别名

• 药物性红斑狼疮
• 药物性系统性红斑狼疮