糖尿病性心肌病

定义

糖尿病心肌病是指在没有明显临床冠状动脉疾病、瓣膜疾病和其他常规心血管危险因素（如高血压和血脂异常）的情况下出现心肌功能障碍。它最初的特点是心肌纤维化、功能失调性重塑和舒张功能障碍，进展到收缩功能障碍和心力衰竭。 其他信息。糖尿病心肌病的发展和进展与心脏胰岛素代谢信号受损、氧化应激增加、一氧化氮生物利用率降低、基于胶原蛋白的心肌细胞和细胞外基质僵化、线粒体和心肌细胞钙处理受损、炎症、肾素-血管紧张素-醛固酮系统激活、心脏自主神经病变、内质网应激、微血管功能障碍和大量心脏代谢异常有关。

Diabetic cardiomyopathy is the presence of myocardial dysfunction in the absence of overt clinical coronary artery disease, valvar disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia. It is initially characterised by myocardial fibrosis, dysfunctional remodeling, and diastolic dysfunction, progressing to systolic dysfunction and heart failure. Additional information. The development and progression of diabetic cardiomyopathy has been linked to impaired cardiac insulin metabolic signaling, increases in oxidative stress, reduced nitric oxide bioavailability, collagen-based cardiomyocyte and extracellular matrix stiffness, impaired mitochondrial and cardiomyocyte calcium handling, inflammation, renin–angiotensin–aldosterone system activation, cardiac autonomic neuropathy, endoplasmic reticulum stress, microvascular dysfunction, and a myriad of cardiac metabolic abnormalities.

索引词 可用于检索该条目的同义词与别名

• 糖尿病性心肌病

编码备注 Coding note

始终指定一个糖尿病的附加编码。

Always assign an additional code for diabetes mellitus.