抗利尿激素不适当分泌综合征
Syndrome of inappropriate secretion of antidiuretic hormone
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- 5A60 垂体功能亢进
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- 5 级
定义
抗利尿激素分泌异常综合征（SIADH）的特征是持续分泌ADH，导致低钠血症、低渗透压和钠尿。确切的患病率尚不清楚。这种疾病在所有年龄组都有描述。SIADH常与肿瘤、肺部疾病、中枢神经系统疾病或药物接触有关。偶有肾上腺、甲状腺或垂体功能不全的患者出现。这种疾病是由编码加压素V2受体的基因功能获得性突变引起。液体限制是最常见的治疗方法。治疗结果与潜在的和相关疾病有关。
Syndrome of inappropriate antidiuretic hormone (ADH) secretion (SIADH) is characterised by continued ADH secretion, leading to hyponatremia, hypoosmolality and natriuresis. Exact prevalence is unknown. The disease has been described in all age groups. SIADH is often associated with tumours, pulmonary disease, central nervous system disorders or exposure to drugs. Occasionally, it is found in patients with adrenal, thyroid or pituitary insufficiency. The disorder is caused by gain-of-function mutations in the gene encoding the vasopressin V2 receptor. Fluid restriction is the most common treatment. The outcome is related to the underlying and associated disorders.
子条目 共 3 条
后组配轴 Postcoordination
该条目未定义后组配轴，直接使用上面的编码即可。后组配是在主干编码之后追加侧别、具体解剖部位、严重程度、病因等细节的可选组合方式，不是必填项。