继发性横纹肌溶解症
Secondary rhabdomyolysis
- 上级条目
- 继发性肌病
- 层级
- 4 级
定义
继发性横纹肌溶解症发生在病原因素的主要作用导致功能或生化状态，有利于肌肉发生缺血、变性、坏死或膜失稳变化，产生横纹肌溶解症的临床和生化特征。最常见的是，横纹肌溶解症继发于代谢紊乱，这种紊乱通常是遗传性的，其原因是异常过度运动、试图对抗阻力而产生的过度等长张力，或昏迷导致肌内压力升高、缺血、缺氧和坏死。继发性横纹肌溶解症也可由多种基因（RYR1、LPIN）突变引起。
Secondary rhabdomyolysis occurs when the primary effect of a aetiological factor results in a functional or biochemical state which is conducive to the development of ischemic, degenerative, necrotic or membrane destabilizing changes in muscle, producing the clinical and biochemical features of rhabdomyolysis. Most frequently, rhabdomyolysis is secondary to a metabolic derangement often genetic in nature, as result of abnormally excessive movement, excessive isometric tension by attempted movement against resistance, or coma leading to increased intramuscular pressure, ischemia, hypoxia and necrosis. Secondary rhabdomyolysis can also be caused by a mutation in various genes (RYR1, LPIN).
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- 继发性横纹肌溶解症
英文词条（1）
- Secondary rhabdomyolysis
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