弥漫性泛细支气管炎

定义

弥漫性泛细支气管炎（DPB）是一种主要影响呼吸性细支气管的特发性炎症性疾病，可导致进行性化脓性和严重阻塞性呼吸障碍。发病于生命的第二至第五个十年，表现为慢性咳嗽、劳累性呼吸困难和咳痰。大多数患者也有慢性副鼻窦炎。如果不治疗，DPB会发展为支气管扩张、呼吸衰竭和死亡。据报道，由于使用大环内酯类抗生素进行长期治疗，预后显著改善，其效果归因于抗炎和免疫调节作用。

Diffuse panbronchiolitis (DPB) is an idiopathic inflammatory disease principally affecting the respiratory bronchioles, causing a progressive suppurative and severe obstructive respiratory disorder. Onset occurs in the second to fifth decade of life and manifests by chronic cough, exertional dyspnoea, and sputum production. Most patients also have chronic paranasal sinusitis. If left untreated, DPB progresses to bronchiectasis, respiratory failure and death. A significant improvement in the prognosis has been reported thanks to the use of long-term therapy with macrolide antibiotics, the effect of which is attributed to an anti-inflammatory and immunoregulatory action.

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• 弥漫性泛细支气管炎