药物或物质所致睡眠相关低通气

定义

药物或物质所致睡眠相关低通气主要表现为慢性通气不足和高碳酸血症，原因是长期服用已知抑制通气动力和/或损害呼吸肌力学的药物或物质（如长效麻醉剂、麻醉药、镇静化合物和肌肉松弛剂）。低氧血症也很常见。一些患者在清醒时也可能出现高碳酸血症。患者可能无症状，也可主诉呼吸困难、胸闷或疲劳。 注：明确诊断需要基于多导睡眠呼吸监测和二氧化碳（CO2）监测（通过动脉、呼气末或经皮测量）的客观证据，并结合被判断为导致症状的药物或药物使用情况。

Sleep-related hypoventilation due to a medication or substance is characterised primarily by chronic hypoventilation and hypercapnia due to prolonged use of medications or substances known to depress ventilatory drive and/or impair respiratory muscle mechanics (e.g. long-acting narcotics, anesthetics, sedative compounds, and muscle relaxants). Hypoxemia is commonly present as well. Hypercapnia may also be present during wakefulness in some patients. Patients can either be asymptomatic or present with complaints of dyspnea, chest tightness, or fatigue. Note: A definitive diagnosis requires objective evidence based on polysomnography with carbon dioxide (CO2) monitoring (by arterial, end-tidal or transcutaneous measures) in the context of medication or substance use that is judged to be causing the symptoms.

索引词 可用于检索该条目的同义词与别名

• 药物或物质所致睡眠相关低通气
• 物质（包括药物）所致睡眠相关低通气
• 药物等物质引起的睡眠相关性低通气